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Paweł Krysiński, professor |
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Affiliation
and Official Address:
Professor
of chemistry
Laboratory of Electrochemistry
Faculty
of Chemistry,
02-093
E-mail: pakrys@chem.uw.edu.pl; Fax: (+4822)
8225996; Tel.: (+4822) 8220211, ext. 389, 286
Education:
1991 habilitation, Department of Chemistry,
1979 Ph.D. Department of Chemistry,
1976 M.Sc. Department of Chemistry,
Career/Employment:
2004 – present professor, Dept. of Chemistry,
1991 – 2004 adjunct (habilitation, with tenure), Dept. of
Chemistry,
1979 – 1991 adjunct, Dept. of Chemistry,
1976 – 1979 assistant, Dept. of Chemistry,
Specialization
and Current Research Interests
Specialization:
(i) Main
field: Physical Chemistry and Electrochemistry
(ii)
Other fields: Interfacial electrochemistry and
biophysics, particularly that of biological interfaces; transfer phenomena
across modified interfaces, biomembranes and their models: self assembled and
Langmuir-Blodgett films, bilayer lipid membranes (BLMs); molecular electronics,
biosensors and energy transduction, interfacial catalysis, conducting polymer
1D and 2D domains within or on the molecular films at the electrode surface
Magnetic nanoparticles (ferrofluids),
surface modifications and applications (e.g., targeted drug delivery)
Current research interest
My
current research covers the area of charge transfer, energy transduction and
molecular electronics in molecular film assemblies (e.g., self-assembled
monolayers on a conducting support, hybrid alkanethiol/phospholipid bilayers,
bilayer lipid membranes (BLMs) and phospholipid bilayers tethered to a
conducting support) This research has the objective getting the insight into
the workings of biomembranes and design and development of systems capable of
biosensing, storing and transducing energy at the molecular level.
Other
area of interest covers functionalization of magnetic nanoparticles with
organic molecules affecting their magnetic properties and applications. One of
the current research is the attachment of anthracycline drugs to the surface of
SPIONs (Superparamagnetic Iron Oxide Nanoparticles) for targeted drug delivery
in the external magnetic field.
I am currently involved in two projects aimed at the supramolecular design of the electrode
surface for molecular recognition and selectivity in electrochemical reactions,
as well as for the surface catalysis. The
goal of these projects is to design, characterize and demonstrate specialized
interfacial structures where a number of biomolecules (e.g., transmembrane
proteins) can be incorporated in a way that retains their biological activity,
while being electrochemically addressable. Such interfacial structures will be
tailored to serve both as matrices for the immobilization of biomolecules and
as stable and electronically conducting molecular junctions
contacting these biomolecules with conducting supports.
Teaching
Physical Chemistry II, course lecture, 3rd
year curriculum,
http://www.chem.uw.edu.pl/people/AMyslinski/informator06/sem6.htm; (str. 13); Program i treść wykładu
Bioelectrochemistry, specialization lecture, semester IIM, together with
Prof. dr hab. Renata
Bilewicz
http://www.chem.uw.edu.pl/people/AMyslinski/informator06/sem8.htm; (str. 23)
Alumni, Students:
Maciej Mazur, DSc. mmazur@chem.uw.edu.pl
http://www.chem.uw.edu.pl/people/MMazur
post-doctoral grant:
NSF-NATO Post-Doctoral Research
Fellowship
with
Prof. Gary J. Blanchard group
currently:
tenure at the Dept. of Chemistry,
Agnieszka Żebrowska, Ph.D. in 2003,
during
graduation one semester
at
Max-Planck Institute
for
Biophysics in Frankfurt,
currently:
Patent Attorney Office.
Monika
Domińska, mdomi@chemistry.msu.edu;
graduated in
2010 at Michigan State University
in
cooperation with the Dept. of Chemistry,
University of Warsaw
Anna Loksztejn,
aloksztejn@chem.uw.edu.pl;
graduated in 2010
in cooperation with:
High
Pressure Research Institute, Polish
Academy of Sciences, dr. hab. W. Dzwolak:
http://www.unipress.waw.pl/Dzwolak
Dorota Nieciecka,
dnieciecka@chem.uw.edu.pl
Ph.D. student 3rd
year curriculum
Krzysztof
Nawara, knawara@chem.uw.edu.pl
Ph.D. student
of the International PhD Programme,
3rd
year curriculum.
2002 Senior fellow at the
Center for Materials Research,
2001
-2002 Visiting Researcher,
Michigan State University, Department of Chemistry, E. Lansing, USA.
1997 Visiting Professor, CNR grant (4 months, won
in competition out of 6 grants for Central and
for
the research project at the University of Florence, Department of Chemistry,
Florence, Italy, with Professor R. Guidelli
1992 – 1994 Visiting Researcher at the
with
Professor M. Majda,
1984 – 1986 Post-doctorate at Michigan State University, Physiology Department, Membrane Biophysics Laboratory,
East
Lansing MI, with Professor H.T. Tien
Research
Funding and International Collaboration
Grants in Force:
2011-2013 Task coordinator: Projekt Badawczy Rozwojowy 501/58-PBR-11 „Mikrobiogniwo i współpracujący z nim czujnik warstwowy” (NCBR
Grant)
Project title: „Microbiofuel cell for layered sensors”
2012-2014
Task coordinator: Polsko-Szwajcarski Program Badawczy PSPB-079/2010 „Projektowanie
Lipidowych Mezofaz Ciekłokrystalicznych jako Nowych Funkcjonalnych Nanomateriałów
dla
Bioenergetyki i Bioczujników”.
Project title: „Tailored Lipidic Mesophases as Novel Functional Nanomaterials in Bioenergetics and Biosensing
Prior Support:
2005-2007
Task coordinator: Projekt Badawczy Zamawiany PBZ18 (Ministry of Education and Science grant PBZ KBN-098/T09/2003)
"Nowa generacja molekularnych warstw przewodzących do
zastosowań w analitycznej diagnostyce
medycznej oraz bioelektronice".
Project title: „New generation of conducting
molecular layers for analytical and medical diagnosis
and bioelectronics.
2000-2003
Project
Coordinator of the State Committee for Scientific Research (Polish governmental
agency) No 3T09A 117 19.
Project
title: Electrochemical
studies on mono- and bimolecular films modified with redox centers
deposited on the electrode surface.
2001-2002 Project
Coordinator of the State Committee for Scientific Research (Polish governmental
agency) grant
Project
title: Synthesis of conducting polymers
with use of alkanethiol monolayers as molecular matrices.
1995-1998
Project
Coordinator of the State Committee for Scientific Research (Polish governmental
agency) grant.
Project
title: Mono- and bimolecular layers at
the electrode surfaces - their
formation and charge transfer
and
separation in such systems.
International Collaboration:
2004-2006 Project coordinator
of the Polish-USA joint research project (PAN-NSF)
Project
title: Characterizing
and Controlling Reactive Group Density at Mono- and Multilayer Interfaces.
2001-2002
Project Coordinator NATO Collaborative Linkage Grant
Project
title: Studies of Molecular
Films at Electrode and Optical Interfaces
1999-2000
Polish
Coordinator of Phare-SCI-TECH II PL9611-02-02 grant for the project preparation
within the EU FP5 1st Horizontal
Programme
"Quality of Life and Management of Living Resources", Key Action:
"The Cell Factory".
Project
title: Solid supported bilayer lipid
membranes with spacer for the incorporation of biomolecules
and
integral proteins, designed for biosensor and drug screening applications.
Participating
countries: Poland, Italy, United Kingdom, Germany, Israel.
1997-2001
Project Coordinator in the Scientific and
Technological Cooperation
Joint
Project (Italy-Poland);
Project
title: Supramolecular design of
electrodes for molecular recognition and selectivity
in
electrochemical reactions
1997-1999
Principal
Investigator in the NATO International Scientific Exchange Programmes LINKAGE
GRANT
(Poland-Italy-Netherlands);
Project
title: Two membrane models for drug
monitoring and sensing.
- Number of papers in refereed
journals: 63
- Number of books: 1 chapter H.
T. Tien, J. Kutnik, P. Krysiński ,
Z. K, Lojewska, "Electronic
Properties of Electroactive Bilayer Lipid Membranes", in: "Electrical
Double Layers in Biology", ed. by M.Blank, (Plenum Press, N.Y.), pp.
149‑168 (1986).
- Number of review papers: 4
Selected recent
publications:
1. Mazur M. Krysiński* P.
Michota-Kamińska A. Bukowska J. Rogalski J. Blanchard G. J., Immobilization
of laccase on gold, silver and indium tin oxide by
zirconium-phosphonate-carboxylate (ZPC) coordination chemistry, Bioelectrochemistry,
71, 15-22, 2007
2. Dominska M., Mazur M.,
Greenough K.P., Koan M.M., Krysiński P.G. Blanchard G. J., Probing
Organization and Communication at Layered Interfaces, Bioelectrochemistry,
70, 421-434, 2007
3. Majewski P, Krysinski P., Synthesis,
surface modifications, and size-sorting of mixed nickel-zinc ferrite colloidal
magnetic nanoparticles, Chem. a European J., 14, 7961-7968, 2008
4. Dominska M, Krysinski P,
Blanchard G.J. Interrogating interfacial organization in planar bilayer
structures, Langmuir, 24, 8785-8793, 2008
5. Brzozowska M., Oberts B.P.,
Blanchard G.J., Majewski J., Krysinski P.
Design and characterization of novel tether layer for coupling a
bilayer lipid membrane to the surface of gold, Langmuir, 25,
9337-9345, 2009
6. Brzozowska M., Krysiński P. Synthesis and
functionalisation of magnetic nanoparticles with covalently bound electroactive
compound doxorubicin, Electrochim. Acta,
54, 5065-5070, 2009
7. Nowicka, A.M., Kowalczyk, A., Donten, M.,
Krysinski P., Stojek, Z., Influence of a magnetic nanoparticle as a drug
carrier on the activity of anticancer drugs: Interactions of double stranded
DNA and doxorubicin modified with a carrier, Anal. Chem., 81,
7474-7483, 2009.
8. Mazur M., Krywko-Cendrowska A., Krysinski P., Rogalski J., Encapsulation of laccase in a conducting
polymer matrix: A simple route towards polypyrrole microcontainers, Synthetic Metals, 159,
1731-1738 2009.
9. Kępińska D., Blanchard G.J., Krysiński P., Stolarski J.,
Kijewska K., Mazur M., Pyrene-loaded polypyrrole microvessels,
Langmuir, 27, 12720, 2011
10. Nieciecka D., Krysiński P., Interactions
of doxorubicin with self-assembled monolayer-modified electrodes:
electrochemical, surface plasmon resonance (SPR) and gravimetric studies, Langmuir,
27, 1100, 2011.
Last modified: Feruary
28th, 2012