Seminar CeNT 19.02.2020
17 lutego 2020

The Centre of New Technologies invites to a seminar by

Dr Ishier Raote

Centre for Genomic Regulation, Barcelona, Spain

Title: TANGO1 in collagen secretion: Function and dysfunction

Date: 19th February 2020 (Wednesday)

Time:  11:00 am

Venue: Centre of New Technologies, Banacha 2C, Lecture Hall 0142 (Ground floor)

Host: Dr Piotr Szwedziak

Secreted collagens compose 25% of our dry body weight and are necessary for tissue organization, skin and bone formation. But how are these bulky cargoes, that are too big to fit into a conventional COPII vesicle, exported from the ER? Our discovery of TANGO1, a ubiquitously expressed, ER-exit-site-resident, transmembrane protein, has made the pathway of collagen secretion amenable to molecular analysis. TANGO1 acts as a scaffold to connect collagens in the lumen to COPII coats on the cytoplasmic side of the ER. However, the growth of the collagen containing mega transport carrier is not simply by accretion of a larger COPII-coated patch of ER membrane, but instead I propose that TANGO1 creates a tunnel for cargo transport between the ER and a post-ER compartment. This mechanism is conceptually different from the conventional model for carrier formation, which posits that membrane is derived entirely from a donor compartment. This proposal revises George Palade’s classical schema of carrier-mediated traffic in the secretory pathway. We have seen that TANGO1 rings the ER exit site and thus organizes a sub-compartment or „isolation chamber” within the ER. To assemble the ring, TANGO1 and its interactors mutually recruit, corral and organize each other. Most recently, we have identified the first TANGO1-associated syndromal disease in humans, which mainly manifests as a collagenopathy. Thus, in the short span of a decade, we have identified TANGO1, described a novel mechanism for its function in collagen secretion thereby proposing a radical revision of the classical views of the secretory pathway and now, we have identified a role of TANGO1 in a novel human collagenopathy.


Seminar CeNT 31.01.2020
03 lutego 2020

The Centre of New Technologies invites to a seminar by

Nuria Selva, PhD, DSc

Institute of Nature Conservation, Polish Academy of Sciences, Cracow

Title: The importance of keeping natural areas road-free

Date: 5th February 2020 (Wednesday)

Time: 1:00 pm

Venue: Centre of New Technologies, Banacha 2C, Lecture Hall 0142 (Ground floor)

Host: Prof. Marta Szulkin


Seminar CeNT 31.01.2020
27 stycznia 2020

The Centre of New Technologies invites to a seminar by

Michał Szymański, PhD

Intercollegiate Faculty of Biotechnology of the University of Gdansk and Medical University of Gdańsk

Title: An interplay between DNA replication and repair in human mitochondria

Date: January 31st, 2020 at 12 p.m.

Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)

Host: prof. Agnieszka Chacińska

Human mitochondrial DNA (mtDNA) replication is initiated from two different origins of replication, OriH and OriL where mitochondrial RNA polymerase (POLRMT) initiates the synthesis of short RNA primers. These primers are then used by human mitochondrial DNA polymerase γ (Polγ) to initiate DNA synthesis. Once initiated, both H-strand and L-strand synthesis proceed continuously until two new daughter molecules are formed. The RNA primers at the 5′-ends of the nascent strands must be removed by nucleases and replaced by DNA. Failure to remove ribonucleotides from mtDNA may impair ligation and DNA synthesis, causing DNA lesions which during subsequent replication cycles can cause double-strand mtDNA breaks and deletions. Number of nucleases have been implicated in primer removal but they either lack necessary enzymatic activity or their mitochondrial localization is under debate. Thus, the molecular mechanism RNA primer removal and subsequent termination of DNA replication in human mitochondria is not well understood. I will demonstrate that human mitochondrial nuclease, crucial for mitochondrial DNA repair, is efficient in removal of RNA primers and in concert with other mitochondrial factors promotes processing and termination of mtDNA replication.


Seminar CeNT 24.01.2020
20 stycznia 2020

The Centre of New Technologies invites to a seminar by

Łukasz Dziewit, Ph.D, D.Sc. and Łukasz Drewniak Ph.D, D.Sc.

Faculty of Biology, University of Warsaw

Title: Metal metabolism in bacteria – from biology to biotechnology

Date: January 24th, 2020 at 12 p.m.

Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)

Host: prof. Joanna Trylska

The treatment of metal-contaminated regions (especially those co-contaminated with other toxic substances) remains one of the most expensive environmental challenges currently faced by many countries. It appears that the employment of microorganisms in biotransformation of metals is a good solution to this problem. However, a key step in the waste management technologies is the understanding of the mechanism of various metals resistance, metabolism and transformation. During the seminar we will present the results of our analyses of metal metabolism in various bacteria (including extremophilic strains from Antarctic regions and ancient mines) and how we exploit this knowledge for development of novel environmental biotechnologies. We will show how we combine the classical environmental microbiology with recent advances in genomics and metagenomics for more successful identification of microbial traits that may maximize the benefits of metals bioremediation technologies. Finally, we will present examples of environmental technologies developed in our laboratory and successfully implemented in Poland and abroad.


“BUW for owls”
16 stycznia 2020

The University of Warsaw Library prolongs its working hours. “BUW for owls” starts on 20th January. Students who will be preparing for exams now can use the library until 5 am.

Mid-year assessment period at the University of Warsaw begins on 28th January. The University of Warsaw Library meets expectations of students and prolongs its opening hours. Students who prefer burning the midnight oil can take part in “BUW for owls” action. From Monday 20th January to Saturday 1st February, the University of Warsaw Library will be open until the first-morning bus meaning until 5 am.

  • On Saturday (January 25th and February 1st) the Library will be open from 9 am to 9 pm, on Sunday (January 26th and February 2nd) the Library will be open from 3 pm to 8 pm.
  • After 10 pm Information Desk, Reading Room and open stacks on levels 1, 2 and 3 will be available;
  • After 10 pm from Monday to Friday, and on Sunday, the Circulation Desk and the Closed Stacks will be closed.
  • The Cloakroom next to Costa Coffee will be open until 5 am.

Only valid library cards holders can take part in “BUW for owls”.

We kindly remind you that during the nights no other drinks but bottled water and no food is allowed in the library.

More information >>

 

Source: www.en.uw.edu.pl


PhD position is available within OPUS 14 NCN grant
15 stycznia 2020

PhD position is available within OPUS 14 NCN grant „Mechanistic investigations for local thermal oxidation of thin MoS2”. Principal Investigator: dr hab. Robert Szoszkiewicz, prof. ucz. Deadline for applications: 16 February 2020. For more info see >> pdf


Seminar CeNT 17.01.2020
14 stycznia 2020

The Centre of New Technologies invites to a seminar by

Witold Konopka, PhD

Nencki Institute of Experimental Biology, Warsaw

Title: microRNA dependent regulation of neuronal plasticity in feeding behavior

Date: January 17th (Friday)

Time: at 12 p.m.

Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)

Host: prof. Marta B. Wiśniewska

Eating behavior of animals is controlled by neuronal circuits in the brain, mainly located within the hypothalamus. Hunger is induced by physiological signals e.g. leptin, informing the brain about energy storages in adipose tissue or glucose deficits during hypoglycemia. Additionally, other non-physiological factors may influence when and what do we eat. Those factors include sensory cues of especially palatable food or are entrained by circadian rhythm. Regulation of activity of neurons involved in the control  of feeding and metabolism is achieved on many levels of gene expression. We are especially interested in post-transcriptional level of protein translation regulated by microRNAs. These short RNAs serve as a guides for the translation inhibiting complex RISC. We have generated transgenic mice with a mutation of the Dicer gene restricted to forebrain neurons of adult mice. The Dicer nuclease is an essential enzyme in the biogenesis of microRNAs. Mice lacking the Dicer gene in the arcuate nucleus of the hypothalamus developed an obesity phenotype due to increased feeding of regular chow diet. We have also examined how different diets: standard, high fat diet, Western diet and ketogenic diet influence microRNA levels in the blood and preference of mice towards consumed diet.


Information meeting on legalisation of stay
07 stycznia 2020

On 17th January, UW Welcome Point organises two information meetings for students who would like to get information on how to legalise their stay in Poland.

In the programme of the meetings:

  •   The legalisation of residence in Poland (visa, permanent residence permit)
  •   Differences between a student visa and a temporary residence permit
  •   The procedure of application for a residence permit
  •   Taking up a job during studies
  •   The legalisation of stay after obtaining a university diploma
  •   Polish descent and Card of the Pole holders’ rights

Both meetings will take place on 17th January in the Auditorium Maximum building (hall “A”) on the Main Campus.

Registration is available on the Welcome Point website.

 

Source: www.en.uw.edu.pl


Seminar CeNT 8.01.2020
03 stycznia 2020

The Centre of New Technologies invites to a seminar by

Joanna Rutkowska, PhD, DSc
Institute of Environmental Sciences, Jagiellonian University, Cracow

Title: „Family secrets revealed: meta-analytical insights into non-genetic maternal and paternal effects”

Date: 8th January 2020 (Wednesday)

Time: 1:00 pm

Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)

Host: Prof. Marta Szulkin


Open call for candidates for rector position at the UW
30 grudnia 2019

The University Council of the University of Warsaw advises the Rector and the Senate of the University of Warsaw and nominates candidates for the Rector position. To ensure transparency and good governance practices, the University Council announces an open call for candidates who are interested in the Rector position and meet the requirements. The deadline for sending applications: 31st January.

Open call for candidates for rector position at the University of Warsaw (pdf)

Applications should be submitted to the University Council by email (university.council@uw.edu.pl) and will be treated confidentially.

The deadline for applications is 31st January 2020.

More information on the University Council of the University of Warsaw

 

Source: www.en.uw.edu.pl